COVID-19 may increase risk of Alzheimer’s, Parkinson’s and stroke: study

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New Danish Study Finds COVID-19 Outpatients Have a Higher Risk of Diagnosis Parkinson’s, Alzheimer’s, stroke and bleeding in the brain compared to patients who tested negative for COVID-19, but according to a recent study published in the journal Frontiers in Neurology in June this year, most neurological disorders after COVID-19 occurred no more often than after other respiratory infections.

“More than two years after the onset of the COVID-19 pandemic, the exact nature and evolution of COVID-19’s impact on neurological disorders remained unclear,” said lead author Dr. Pardis Zarifkar is a member of the Department of Neurology at Rigshospitalet in Copenhagen, Denmark.

“Previous studies have established an association with neurological syndromes, but it is still unknown if COVID-19 is also affecting incidence of specific neurological diseases and whether it differs from other respiratory infections.

The study, which was recently presented at the 8th Congress of the European Academy of Neurology, found that 43,375 people tested positive for COVID-19 and 876,356 people tested negative for the disease out of a total of 919,731 participants.

Small, pea-sized organelles similar to the human midbrain, which are three-dimensional, multicellular tissue constructs in vitro that mimic the human midbrain, are grown from human stem cells so that scientists can study how the human brain develops and communicates.  A new Danish study found that outpatients with COVID-19 have a higher risk of being diagnosed with Parkinson's disease, Alzheimer's disease, stroke and cerebral hemorrhage compared to patients who test negative for COVID-19, but most neurological disorders were not more frequent after COVID -19 than after other respiratory infections, according to a recent study published in the journal Frontiers in Neurology in June this year.

Small, pea-sized organelles similar to the human midbrain, which are three-dimensional, multicellular tissue constructs in vitro that mimic the human midbrain, are grown from human stem cells so that scientists can study how the human brain develops and communicates. A new Danish study found that outpatients with COVID-19 have a higher risk of being diagnosed with Parkinson’s disease, Alzheimer’s disease, stroke and cerebral hemorrhage compared to patients who test negative for COVID-19, but most neurological disorders were not more frequent after COVID -19 than after other respiratory infections, according to a recent study published in the journal Frontiers in Neurology in June this year.
(Hyunsoo Sean Jae, Duke-NUS Medical School)

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The study used electronic health records that covered approximately 50% of the population of Denmark, which has an estimated population of 3 million.

The study analyzed those who tested positive for COVID-19 and bacterial pneumonia in hospital settings between February 2020 and November 2021, as well as flu patients from the corresponding pre-pandemic period from February 2018 to November 2019.

Of the 43,375 patients who tested positive for COVID-19, 35,362 were in outpatient care and 8,013 were hospitalized.

The researchers found that outpatients who tested positive for COVID-19 had a 3.5-fold increased risk of being diagnosed with Alzheimer’s disease, a 2.6-fold increased risk of Parkinson’s disease, a 2.7-fold increased risk of ischemic stroke, and a 4.8-fold increased risk of increased risk of intracerebral hemorrhage. there is a hemorrhage in the brain.

But when researchers compared relative risk of neurological disorders in other respiratory diseases, such as influenza, the increased risk of most neurological diseases in patients with COVID-19 was not higher than in patients with other respiratory diseases, with one exception.

Brain disease diagnosis with doctor viewing magnetic resonance imaging (MRI) film diagnosing neurodegenerative disease problem in elderly aging patient for neurological treatment.  But when the researchers compared the relative risk of neurological disorders with other respiratory illnesses, such as the flu, the increased risk of most neurological conditions was not higher in patients with COVID-19 compared to those diagnosed with other respiratory illnesses—with one exception.

Brain disease diagnosis with doctor viewing magnetic resonance imaging (MRI) film diagnosing neurodegenerative disease problem in elderly aging patient for neurological treatment. But when the researchers compared the relative risk of neurological disorders with other respiratory illnesses, such as the flu, the increased risk of most neurological conditions was not higher in patients with COVID-19 compared to those diagnosed with other respiratory illnesses—with one exception.
(iStock)

Researchers have found that the risk of ischemic stroke in hospitalized patients with COVID-19 is increased compared to hospitalized patients with influenza.

The study was limited because it did not take into account potentially confounding variables such as socioeconomic factors, lifestyle, pre-existing comorbidities, and length of hospitalization.

Medical illustration of a brain with stroke symptoms.  Researchers have found that the risk of ischemic stroke in hospitalized patients with COVID-19 is increased compared to hospitalized patients with influenza.

Medical illustration of a brain with stroke symptoms. Researchers have found that the risk of ischemic stroke in hospitalized patients with COVID-19 is increased compared to hospitalized patients with influenza.
(iStock)

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Although the study covered a large proportion of the population, it was only able to consider a fraction of the absolute number of individuals tested in the country, as only tests for COVID-19 performed in hospital facilities are registered in the Danish electronic health record system that the study used for analysis. records.

“While risk of ischemic stroke was increased with COVID-19 compared with influenza, it is reassuring that most neurological disorders do not appear to be more common after COVID-19 than after influenza or community-acquired bacterial pneumonia,” the researchers concluded.

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“The incidence of multiple sclerosis, myasthenia gravis, Guillain-Barré syndrome, and narcolepsy did not differ after COVID-19, influenza, and bacterial pneumonia,” the study says.

“These results will help us better understand the long-term impact of COVID-19 on the body and the role that infections play in neurodegenerative diseases and strokes,” Zarifkar said.