Study Finds Uterine Transplant Allows US Women to Have Successful Pregnancies

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More than half of the women in the United States who received a uterus transplant later had successful pregnanciesshows a new study.

Between 2016 and 2021, 33 women in the US have had womb transplants, and so far 19 of them, or 58%, have given birth to a total of 21 babies, researchers reported Wednesday in JAMA Surgery.

“Uterus transplantation should be considered a clinical reality in the US,” the researchers wrote.

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All women had so-called absolute uterine infertility, that is, they were either born without a uterus or needed to have it removed.

More than a million women in the US could potentially benefit from uterine transplants, study leader Dr. This was reported by Lisa Johannesson from the Baylor University Medical Center in Dallas.

In 74% of recipients, the uterus was still functioning one year after transplantation. In this group, 83% had live birthsresearchers report.

All children were born by caesarean section on average 14 months after transplantation. More than half of them were born after 36 weeks of pregnancy.

Over a million women in the US could potentially benefit from uterine transplantation, which currently has a success rate of over 50%.

Over a million women in the US could potentially benefit from uterine transplantation, which currently has a success rate of over 50%.
(Reuters/Regis Duvignau/File photo)

After the recipient is in laborthe transplanted uterus is removed to avoid the need for lifelong immunosuppressant medication.

The surgeries in the US, performed at Baylor University Medical Center, Cleveland Clinic and University of Pennsylvania Hospital, are among more than 100 uterine transplants performed worldwide to date.

Cost can be a barrier for some women.

“Uterus transplantation is the de facto treatment for infertility,” and some insurance companies may refuse to cover it, study co-author Dr. B. Giuliano Testa of Baylor said in an email.

“The womb transplant coverage is part of a larger discussion regarding fertility treatment coverage in general,” Johannesson said.

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In two-thirds of transplants in the United States, the uterus was obtained from a living donor, with about one in four of them undergoing a transplant. complication after surgery.

“Reducing the risk to living donors should be the goal … if the pool of deceased donors is not adequate,” says the doctor. Rachel Forbes and Seth Karp of Vanderbilt University Nashville wrote in an accompanying editorial.