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Singapore confirmed this is the first local case of monkeypox, the health ministry said late Wednesday.
The patient is a 45-year-old Malaysian citizen living in Singapore. He tested positive on Wednesday.
As of Wednesday, three close contacts of the man have been identified and all will be quarantined for 21 days from their last contact with him, the statement said.
He had symptoms such as skin lesions in the lower abdomen, fatigue, swollen lymph nodes, fever, and sore throat.
His condition is stable and he is currently at a branch of the National Center for Infectious Diseases in Singapore, the ministry said, adding that the transmission risk to the general public remains low.
The patient is not related to the imported case that was announced last month.
Over 6,000 cases of monkeypox have now been reported in 58 countries during the current outbreak. World Health Organization said.